Evolution of the Immune Response against Recombinant Proteins (TcpA, TcpB, and FlaA) as a Candidate Subunit Cholera Vaccine
نویسندگان
چکیده
منابع مشابه
Evolution of the Immune Response against Recombinant Proteins (TcpA, TcpB, and FlaA) as a Candidate Subunit Cholera Vaccine
Vibrio cholerae is the causative agent of cholera and annually leads to death of thousands of people around the globe. Two factors in the pathogenesis of this bacterium are its pili and flagella. The main subunits of pili TcpA, TcpB, and FlaA are the constituent subunit of flagella. In this study, we studied the ability of pili and flagella subunits to stimulate immune responses in mice. After ...
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background and objectives: the toxin co-regulated pilus a (tcpa) has been described as a criti- cal pathogenicity factor of vibrio cholerae . tcpa is a candidate for making subunit vaccine against chol- era. the aim of this study was to produce a candidate vaccine by expressing recombinant tcpa in e. coli . materials and methods: i...
متن کاملRecombinant toxin-coregulated pilus A (TcpA) as a candidate subunit cholera vaccine
BACKGROUND AND OBJECTIVES The toxin co-regulated pilus A (TcpA) has been described as a critical pathogenicity factor of Vibrio cholerae. TcpA is a candidate for making subunit vaccine against cholera. The aim of this study was to produce a candidate vaccine by expressing recombinant TcpA in E. coli. MATERIALS AND METHODS In this study, the toxin co-regulated pilus A gene from EL-Tor, V. chol...
متن کاملارزیابی و مقایسه تیتر آنتی بادی علیه پروتئین های نوترکیب منفرد، مخلوط و کایمر CTXB، TCPA وTCPA CTXB-
Background: Cholera as diarrheal illness is one of the most important causes of death and people's disability in different societies. Colonization factor pili (tcpA) and cholera toxin are the most important factors in the pathogenesis of Vibrio Cholera. B subunit of cholera toxin (ctxB) and tcpA have the ability to induce immune responses. The aims of this study was production of CTXB, TCPA, CT...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2017
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2017/2412747